10% Enrofloxacin Oral Solution

Pharmacokinetics

This product is well absorbed after oral administration in most animals. The bioavailability of oral administration in chickens is 62.2% ~ 84%, which is widely distributed in poultry and can well enter tissues and body fluids (including bones). Except for cerebrospinal fluid, the drug concentration in almost all tissues is higher than that in plasma. Hepatic metabolism is mainly to remove the ethyl group of 7-piperazine ring to generate ciprofloxacin, followed by oxidation and glucuronic acid conjugation. It is mainly excreted by the kidneys (with tubular secretion and glomerular filtration), and 15% to 50% is excreted unchanged in the urine. The elimination half-life of this product after oral administration in chickens is 9.1 to 14.2 hours

Drug interactions

 (1) This product has a synergistic effect in combination with aminoglycosides or broad-spectrum penicillins.

Heavy metal ions such as Ca2 +, Mg2 +, Fe3 + and Al3 + can chelate with this product and affect absorption.

(2)When used in combination with theophylline and caffeine, the plasma protein binding rate can be reduced, the concentrations of theophylline and caffeine can be abnormally increased, and even the symptoms of theophylline poisoning can occur.

(3)This product has the effect of inhibiting hepatic drug enzymes, which can reduce the clearance rate of drugs mainly metabolized in the liver and increase the plasma concentration.

(4)Action and use: Fluoroquinolone antibacterial drugs. Used for bacterial diseases and mycoplasma infection in chickens.

Dosage and administration

Mixed drink: 0.5 ~ 0.75 ml for poultry per 1 L of water.

Adverse reactions

(1) Degeneration of cartilage occurs in young animals, affecting bone development and causing lameness and pain.

(2) Digestive system reactions include loss of appetite, diarrhea, etc.

Precautions

It is contraindicated in laying hens during the laying period

Withdrawal period

Avian: 8 days

Storage

Sealed and stored, protected from light.