The results of kinetic studies showed that acetylaminoavermectin can be absorbed by a variety of routes, such as oral or percutaneous, subcutaneous, and intramuscular injection, with good efficacy and rapid distribution throughout the body. However, to date, there are only two commercial preparations of acetylaminoavermectin: pouring agent and injection. Among them, the application of pouring agent in virulent animals is more convenient; while although the bioavailability of injection is high, the injection site pain is obvious and the disturbance to animals is greater. It has been found that oral absorption is superior to transdermal absorption for the control of nematodes and arthropods that feed on blood or body fluids.
Physicochemical properties The drug substance is a white crystalline solid at room temperature, with a melting point of 173 ° C and a density of 1.23 g/cm3. Because of its lipophilic group in its molecular structure, its lipid solubility is high, it is soluble in organic solvents such as methanol, ethanol, propylene glycol, ethyl acetate, etc., has the greatest solubility in propylene glycol (greater than 400 g/L), and is almost insoluble in water. Eprinomectin is easy to photolyze and oxidize, and the drug substance should be protected from light and stored under vacuum.
Eprinomectin has a good control effect in the control of internal and ectoparasites such as nematodes, hookworms, ascaris, helminths, insects and mites in various animals such as cattle, sheep, camels, and rabbits. It is mainly used for the treatment of gastrointestinal nematodes, itching mites and sarcoptic mange in livestock.
Eprinomectin injection 1%, Eprinomectin Pour-on Solution 0.5%