20% Sulfadiazine+4% Trimethoprim Injection

Active Ingredient : Sulfadiazine 20.00% w / v. Trimethoprim 4.00% w/v   Pharmacological action Sulfadiazine is a moderately effective sulfa drug for systemic use and is a broad-spectrum bacteriostatic agent. Its mechanism of action is because it is structurally similar to p-aminobenzoic acid (PABA) and can compete with PABA to act on the dihydrofolate synthase in bacteria, thereby preventing PABA from being used as a raw material to synthesize tetrahydrofolate required by bacteria, thereby inhibiting The synthesis of bacterial protein plays an antibacterial effect. Indlcations :   This Injectable Solution is indicated in the treatment of systemic infections caused by or associated with organisms sensitive to the Trimethoprim: Sulfadiazine combination. The spectrum of activity includes both Gram-positive and Gram-negative organisms including: Actinobacilli, Actinomycae, Bordetella spp, Brucella Corynebacteria, Escherichia coli, Haemophilus spp. Klebsiella spp, Pasteurella spp, Pneumococci. Proteus, Salmonella spp. Staphylococci, Streptococci, Vibrio. Dosage : Cattle: The recommended dose rate is 15 mg of active ingredients per kg body weight (1 ml per 16kg body weight) by intramuscular or slow intravenous injection. Horses: The  recommended dose rate is 15 mg of active ingredients per kg body weight (1 ml per 16 kg body weight), by slow intravenous injection. Dogs and Cats: The recommended dose rate is 30mg of active ingredients per kg bodyweight (1 ml per 8 kg body weight ). by subcutaneous injection only. Contraindications : The injection should not be given by routes other than those recommended. Not to be administered intraperitoneally, intra - arterially or intrathecally. Do not administer to animals with known sulphonamide sensitivity, severe liver parenchymal  damage or blood dyscrasias. Special Warnings : 1 For intravenous administration the product should be warmed to body temperature and  injected slowly over as long a period as is reasonably practical. 2 At the first sign of intolerance the injection should be interrupted and shock treatment  initiated. Adequate drinking water should be available during the therapeutic effect of the product. Withdrawal Period : Cattle : Meat - 12 days Milk - 4  hours. Storage : Protect from direct sunlight and store below 30C.